Manual Diaphragm Replacement Valves

The ARTeSYN® Diaphragm Replacement Valves (DRVs) are a direct drop-in replacement for your existing stainless steel diaphragm valves, enabling the customer to switch over easily and adopt single-use processing practices.

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The ARTeSYN® Diaphragm Replacement Valve (DRV) has all the features of a traditional diaphragm valve, therefore, it is a great alternative to diaphragm valve. Their ergonomic design allows for rapid and easy liner changes and the valves come in a 1/2” to 1 1/2” clamp size and 0.37"ID to 1.37"ID range. The DRVs can be used with purposefully engineered and molded ARTeSIL® silicone liners in both individual valves and valve arrays. These matched valve and liner designs allow for exceptional fluid control, removing dead-legs and significantly low hold-up volumes. You simply replace and dispose of each liner/insert after each application, which is more efficient than cleaning and reusing a traditional stainless-steel diaphragm valve.


  • Reduced down time
  • No cleaning validation
  • No batch-to-batch cross contamination risk
  • Highest reliability for critical valves
  • Safe, reliable and simplified processing
  • No entrapment areas
  • No product loss
  • No shear stress on cells and proteins compared to traditional diaphragm valves
  • Lower pressure drop, reduced process equipment size
  • Suits both pressurized and unpressurized applications
  • No changes in heat sterilization method of choice

Upstream applications

Media and buffer preparation
Cell clarification/harvest

Downstream applications

Downstream Buffer Exchange
Downstream Virus Inactivation
Downstream Concentration
Downstream Fractionation
Downstream Transfer
Downstream Finish Filling