TFF - Tangential Flow Filtration

ARTeSYN's® Single-Use Tangential Flow Filtration Systems (TFFs) are designed for applications from lab scale to fully automated cGMP operation. They feature significantly reduced hold volumes and all product contact materials are disposable. Over-concentration and dilution of your final product is simplified due to the smallest retentate volumes for a given flow rate in the industry.
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Modifiable for ultrafiltration, microfiltration or diafiltration, they are configurable to accommodate multiple brands of membrane elements. They can be adapted for any membrane format from cassettes to hollow-fiber modules with membrane surface areas ranging from 0.05 – 10 m². The cassette-based TFF holders are available in hydraulically-compressed configurations.


  • Scalable design

  • 10x reduction in hold-up volumes compared to current norms

  • Ease of setup with quick SU liner change-outs

  • Multiple UF/DF membrane elements

  • Fully automated operation: Either Local PLC or DCS controlled

  • Secure recording and retransmission of archival data with GAMP Part 11 compliance

  • Multiple SU sensor types available

  • Programs secured to operator access level

  • Patented ARTeSYN® valve arrays

Upstream applications


Downstream applications

Downstream Filtration